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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mefloquine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mefloquine
UMLS_CUI
  • C0025153
CAS_Registry
  • 53230-10-7
FDA_UNII_Code
  • TML814419R
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 711805
PDQ_Closed_Trial_Search_ID
  • 711805
Chemical_Formula
  • C17H16F6N2O
Legacy_Concept_Name
  • Mefloquine
CHEBI_ID
  • CHEBI:63609
FULL_SYN
  • MEFLOQUINEPTFDATML814419R
  • MefloquinePTNCI
DEFINITION
  • A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.NCI
code
  • C61827
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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