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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Aprepitant
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Aprepitant
UMLS_CUI
  • C1176306
CAS_Registry
  • 170729-80-3
FDA_UNII_Code
  • 1NF15YR6UY
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 454517
PDQ_Closed_Trial_Search_ID
  • 454517
Chemical_Formula
  • C23H21F7N4O3
Legacy_Concept_Name
  • Aprepitant
CHEBI_ID
  • CHEBI:499361
FULL_SYN
  • aprepitantPTNCI-GLOSSCDR0000468778
  • EmendPTNCI-GLOSSCDR0000512781
  • EmendBRNCI
  • MK-0869CNNCI
  • L-754030CNNCI
  • APREPITANTPTFDA1NF15YR6UY
  • 5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-oneSNNCI
  • ONO-7436CNNCI
  • AprepitantPTNCI
DEFINITION
  • A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.NCI
code
  • C49173
sameAs
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