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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sulfisoxazole Acetyl
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sulfisoxazole Acetyl
UMLS_CUI
  • C0081437
CAS_Registry
  • 80-74-0
FDA_UNII_Code
  • WBT5QH3KED
Contributing_Source
  • FDA
Chemical_Formula
  • C13H15N3O4S
Legacy_Concept_Name
  • Sulfisoxazole_Acetyl
FULL_SYN
  • SULFISOXAZOLE ACETYLPTFDAWBT5QH3KED
  • N-3,4-Dimethylisoxazol-5-yl-N-sulphanilylacetamideSNNCI
  • Acetamide, N-((4-aminophenyl)sulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)-SNNCI
  • Sulfisoxazole AcetylPTNCI
  • GantrisinBRNCI
DEFINITION
  • An ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI
code
  • C47741
sameAs
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