About: Heparin Binding Growth Factor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Heparin Binding Growth Factor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Heparin Binding Growth Factor
UMLS_CUI
  • C0599765
Legacy_Concept_Name
  • Heparin_Binding_Growth_Factor
FULL_SYN
  • Heparin Binding Growth FactorPTNCI
DEFINITION
  • Exhibiting high affinity for heparin, Heparin-Binding Growth Factors (HBGF) control proliferation and differentiation of mesenchymal, epithelial, and neuroectodermal cells. Heparin may store some growth factors in the extracellular matrix, stabilize these proteins, and protect them. For some factors, heparin binding is essential to interact with receptors; it enhances the activity of some HBGF. Class 1 factors comprise acidic proteins, related to (acidic) aFGF. Class 2 factors comprise basic proteins, related to (basic) bFGF. HBGFs appear to be products of different genes; some may not be mitogenic or secreted. Current members include FGF-1, FGF-2, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, FGF-8, FGF-9, FGF-10, FGF-11, FGF-12, FGF-13, FGF-14, FGF-15, FGF-16, FGF-17, FGF-18, FGF-19, FGF-20, FGF-21, FGF-22, and FGF-23. (NCI)NCI
code
  • C41029
is rdf:first of
is someValuesFrom of
is Has_Target of
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