About: Immune activation during polyoma BK virus infection after renal transplantation     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz:8890 associated with source document(s)

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Description
  • To monitor the levels of BK viral DNA in the serum and urine in renal transplant recipients. To demonstrate, using molecular biology methods - analysis of expression of selected proinflammatory genes, that monitoring of the level of expression of selected genes of proinflammatory cytokines in the urine of patients with active BKV infection in combination with determination of the number of BKV copies is a suitable diagnostic tool for predicting the long-term fate of the kidney graft. To establish whether there is a relation between the levels of expression of these genes in the urine and in the renal parenchyma biopsy sample. (en)
  • Monitorace hladin BK virové DNA v séru a moči u pacientů po transplantaci ledviny. Molekulárně biologickými metodami (analýza exprese vybraných genů pro cytokiny a chemokiny) prokázat, že sledování míry exprese vybraných genů cytokinů v moči pacientů s aktivní BKV infekcí v kombinaci se stanovením počtu kopií BKV je vhodným diagnostickým nástrojem pro predikci dlouhodobého osudu transplantované ledviny. Zjistit zda existuje vztah mezi mírou exprese genů pro cytokiny a chemokiny v moči a v bioptické tkáni transplantované ledviny.
Title
  • Immune activation during polyoma BK virus infection after renal transplantation (en)
  • Imunitní aktivace v průběhu infekce polyoma BK viru po transplantaci ledviny
skos:notation
  • NS9714
http://linked.open...avai/cep/aktivita
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http://linked.open...ep/celkoveNaklady
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  • BK virus; Gene expression; Cytokines; Renal transplantation; Chemokines; Polyomaviruses (en)
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  • Molecular mechanisms involved in the succesful immune control of polyoma BKV infection involve B cell and T cell related gene networks. (en)
  • Molekulární mechanizmy kontroly BK virové infekce u nemocných po transplantaci ledviny zahrnují sítě spojené s funkcí B lymfocytů a T lymfocytů. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • BK virus
  • Chemokines
  • Cytokines
  • Gene expression
  • Renal transplantation
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