About: Modification of enzymes metabolizing xenobiotics during ageing     Goto   Sponge   NotDistinct   Permalink

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Description
  • On ageing of animal organisms, proteins are impaired by oxidation and glycation of proteins (non-enzymatic glycation and glycoxidation). Physiological functions of glycated proteins are impaired and glycated enzymes lose or change their catalytic activity. Rising advanced glycation end-products (AGE) can serve as suitable markers of ageing. The aim of proposed project is to gain knowledge about modification of selected enzymes by glycation during ageing. Glutathione S-transferase and 11b-hydroxysteroid dehydrogenase will be studied enzymes. Methylglyoxal, the glycation intermediate with strong glycating potential, will be the glycating agent. The study will start with glycation of purified enzymes in vitro. The measured parameters will be catalytic activity, fluorescent AGE formation (pentosidine), and carbonyl and thiol group concentration. In the next phase, glycation of selected enzymes will be studied in primary culture of isolated rat hepatocytes. Obtained results can contribute to gaining new information about changes in metabolism of xenobiotics during ageing. (en)
  • Hlavním cílem projektu bude získat poznatky o modifikaci vybraných biotransformačních enzymů glykoxidací in vitro a v experimentech s primární kulturou potkaních hepatocytů.
Title
  • Modification of enzymes metabolizing xenobiotics during ageing (en)
  • Modifikace enzymů metabolizujících xenobiotika v průběhu stárnutí
skos:notation
  • GP524/09/P121
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  • neenzymová glykace; glykoxidace; biotransformační enzymy; stárnutí (en)
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  • The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en)
  • Řešení projektu proběhlo na vynikající úrovni, a to jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
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  • biotransformační enzymy
  • glykoxidace
  • neenzymová glykace
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