About: HDAC Inhibitor 4SC-202     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HDAC Inhibitor 4SC-202
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • HDAC Inhibitor 4SC-202
NCI_META_CUI
  • CL429405
PDQ_Open_Trial_Search_ID
  • 700110
PDQ_Closed_Trial_Search_ID
  • 700110
FULL_SYN
  • 4SC-202CNNCI
  • HDAC Inhibitor 4SC-202PTNCI
DEFINITION
  • An orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.NCI
code
  • C96797
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