About: ULvWF Multimer-targeting Agent ARC1779     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • ULvWF Multimer-targeting Agent ARC1779
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • ULvWF Multimer-targeting Agent ARC1779
PubMedID_Primary_Reference
  • 19479665
UMLS_CUI
  • C2351141
PDQ_Open_Trial_Search_ID
  • 694584
PDQ_Closed_Trial_Search_ID
  • 694584
FULL_SYN
  • ULvWF Multimer-targeting Agent ARC1779PTNCI
  • ARC1779CNNCI
DEFINITION
  • An optimized, second-generation, PEGylated aptamer with antithrombotic property. ULvWF multimer-targeting agent ARC1779 blocks the binding of von Willebrand factor (vWF), via the A1 domain, and ultra-large vWF multimers to platelets, as well as interferes with the binding of platelet receptor glycoprotein Ib, thus reducing platelet adhesion, aggregation and thrombus growth in arterial beds. Unlike other antiplatelet agents, this aptamer can be readily reversed by binding to a complementary sequence of oligonucleotides, and may therefore offer potential therapeutic benefit in surgery.NCI
code
  • C95742
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 13 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software