About: Atorvastatin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Atorvastatin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Atorvastatin
UMLS_CUI
  • C0286651
CAS_Registry
  • 134523-00-5
FDA_UNII_Code
  • A0JWA85V8F
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin.NCI-GLOSS
Chemical_Formula
  • C33H35FN2O5
Legacy_Concept_Name
  • Atorvastatin_Base
CHEBI_ID
  • CHEBI:39548
FULL_SYN
  • ATORVASTATINPTFDAA0JWA85V8F
  • AtorvastatinPTNCI
  • atorvastatinPTNCI-GLOSSCDR0000514415
  • (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-pyrrole-1-heptanoic AcidSNNCI
  • (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic AcidSNNCI
DEFINITION
  • A synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles. This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)NCI
code
  • C61527
is Has_Free_Acid_Or_Base_Form of
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