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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Captopril
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Captopril
NSC_Code
  • 719847
UMLS_CUI
  • C0006938
CAS_Registry
  • 62571-86-2
Accepted_Therapeutic_Use_For
  • Hypertension; Heart failure; Left ventricular dysfunction; Diabetic nephropathy
In_Clinical_Trial_For
  • Radiation-induced side effects; unspecified solid tumor
FDA_UNII_Code
  • 9G64RSX1XD
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37824
PDQ_Closed_Trial_Search_ID
  • 37824
Chemical_Formula
  • C9H15NO3S
Legacy_Concept_Name
  • Captopril
CHEBI_ID
  • CHEBI:3380
FULL_SYN
  • CaptoprilPTDCP06714
  • (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-prolineSNNCI
  • CAPTOPRILPTFDA9G64RSX1XD
  • CapotenBRNCI
  • CaptoprilPTNCI
  • captoprilPTNCI-GLOSSCDR0000044878
DEFINITION
  • A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)NCI
code
  • C340
is someValuesFrom of
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