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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tenecteplase
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Tenecteplase
UMLS_CUI
  • C0872913
CAS_Registry
  • 191588-94-0
FDA_UNII_Code
  • WGD229O42W
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Tenecteplase
FULL_SYN
  • TENECTEPLASEPTFDAWGD229O42W
  • TenecteplasePTNCI
  • TNKaseBRNCI
  • TNK-tPASYNCI
DEFINITION
  • A 527 amino acid glycoprotein and the modified form of the naturally occuring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction.NCI
code
  • C29489
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