About: HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302
NCI_META_CUI
  • CL428372
PDQ_Open_Trial_Search_ID
  • 696572
PDQ_Closed_Trial_Search_ID
  • 696572
FULL_SYN
  • HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302PTNCI
  • MM-302CNNCI
DEFINITION
  • An antibody-targeted lipidic nano-carrier containing the antineoplastic anthracycline antibiotic doxorubicin encapsulated within liposomes, and conjugated to a monoclonal antibody against the human epidermal growth factor receptor 2 (HER2), with potential antitumor activity. Upon administration of HER2-targeted liposomal doxorubicin hydrochloride MM-302, the immunoliposome allows for specific delivery of doxorubicin to tumors overexpressing the HER2 receptor. Once inside the HER2-expressing tumor cells, doxorubicin intercalates into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication and RNA synthesis. Compared to doxorubicin alone or liposomal doxorubicin, targeted liposomal delivery of doxorubicin improves efficacy while lowering the toxicity profile. HER2, a tyrosine kinase receptor, is overexpressed in many cancer cell types.NCI
code
  • C96038
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