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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pegaptanib Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Pegaptanib Sodium
UMLS_CUI
  • C0967532
CAS_Registry
  • 222716-86-1
FDA_UNII_Code
  • 3HP012Q0FH
Contributing_Source
  • FDA
Chemical_Formula
  • C15H28N3O6(C2H4O)n(C2H4O)n.28Na
FULL_SYN
  • ZalbinBRNCI
  • Pegaptanib SodiumPTNCI
  • EYE001CNNCI
  • NX1838CNNCI
  • PEGAPTANIB SODIUMPTFDA3HP012Q0FH
DEFINITION
  • The sodium salt form of pegaptanib, a 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the activity of the extracellular vascular endothelial growth factor, specifically the 165-amino acid isoform (VEGF165). This prevents VEGF165 from binding to VEGF receptors, thereby blocking angiogenesis as well as preventing VEGF165-induced increases in vessel permeability. VEGF165 is preferentially involved in pathological ocular neovascularisation.NCI
code
  • C95230
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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