About: HDAC inhibitor CG200745     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HDAC inhibitor CG200745
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • HDAC inhibitor CG200745
NCI_META_CUI
  • CL426037
PDQ_Open_Trial_Search_ID
  • 688308
PDQ_Closed_Trial_Search_ID
  • 688308
FULL_SYN
  • HDAC inhibitor CG200745PTNCI
  • CG200745CNNCI
  • (E)-N(1)-(3-(dimethylamino)propyl)-N(8)-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamideSNNCI
DEFINITION
  • A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CG200745 inhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.NCI
code
  • C94225
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