About: Collecting Duct Acid Secretion Pathway     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Collecting Duct Acid Secretion Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Collecting Duct Acid Secretion Pathway
UMLS_CUI
  • C2984304
KEGG_ID
  • hsa04966
ALT_DEFINITION
  • One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate.KEGG
FULL_SYN
  • Collecting Duct Acid Secretion PathwayPTNCI
  • Collecting duct acid secretionPTKEGG
code
  • C91493
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