About: Plasmid Encoding Antiangiogenic Metargidin Peptide     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Plasmid Encoding Antiangiogenic Metargidin Peptide
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Plasmid Encoding Antiangiogenic Metargidin Peptide
NCI_META_CUI
  • CL413626
PDQ_Open_Trial_Search_ID
  • 663943
PDQ_Closed_Trial_Search_ID
  • 663943
FULL_SYN
  • Peptide AMEPSYNCI
  • AMEPFBNCI
  • Plasmid Encoding Antiangiogenic Metargidin PeptidePTNCI
DEFINITION
  • A plasmid encoding the protein antiangiogenic metargidin plasmid (AMEP), the disintegrin domain of ADAM-15 (metargidin), with potential antiangiogenic and antimetastatic activities. Upon intratumoral electrotransfer of plasmid encoding AMEP, AMEP binds to cellular integrin receptors alpha-v-beta-3 (avb3) and alpha-5-beta-1 (a5b1), which are upregulated on activated endothelial cells and a variety of tumor cells. Binding to the integrin receptors may inhibit angiogenesis and may inhibit tumor cell proliferation.NCI
code
  • C90537
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