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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dalantercept
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Dalantercept
NCI_META_CUI
  • CL413544
CAS_Registry
  • 1186210-24-1
FDA_UNII_Code
  • EGC16R10V0
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 658276
PDQ_Closed_Trial_Search_ID
  • 658276
Chemical_Formula
  • C3206H4960N904O976S38
FULL_SYN
  • DalanterceptPTNCI
  • Activin Receptor-like Kinase 1 Inhibitor ACE-041SYNCI
  • ACE-041CNNCI
  • ALK1-Fc Fusion Protein ACE-041SYNCI
  • DALANTERCEPTPTFDAEGC16R10V0
DEFINITION
  • A soluble fusion protein containing the extracellular domain of activin receptor-like kinase-1 (ALK1) fused to a human Fc domain (ALK1-Fc fusion protein), with potential antiangiogenic and antineoplastic activities. Upon administration, dalantercept binds to various ALK1 ligands, preventing activation of tumor cell ALK1 receptors and so inhibiting the ALK1 signaling pathway; growth factor-induced angiogenesis is thus inhibited, which may result in the inhibition of tumor cell proliferation and tumor cell death. ALK1 is a type I cell surface receptor with serine/threonine kinase activity that mediates signaling by members of the transforming growth factor-beta (TGFbeta) superfamily and plays a key role in angiogenesis; ligands for this receptor include TGFbeta1 and TGFbeta2. The Fc moiety of this fusion protein mediates clearance of ligand-fusion protein complexes by the reticuloendothelial system (RES).NCI
code
  • C88296
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