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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prothrombin
equivalentClass
OMIM_Number
  • 176930
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Prothrombin
NCI_META_CUI
  • CL411527
Legacy_Concept_Name
  • Prothrombin_Gene_Product
FULL_SYN
  • ProthrombinPTNCI
  • Factor IISYNCI
  • Coagulation Factor IISYNCI
  • EC 3.4.21.5SYNCI
Swiss_Prot
  • P00734
DEFINITION
  • Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen.NCI
DesignNote
  • Prothrombin protein can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain. (UniProt)
  • Prior to secretion, prothrombin is modified to have gamma-carboxyglutamyl residues, resulting from the carboxylation of glutamyl residues by vitamin K-dependent gamma-carboxylase. These modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. (UniProt)
  • Prothrombin activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. (UniProt)
  • Prothrombin catalyzes the cleavage of Arg-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. (UniProt)
code
  • C82854
is Is_Related_To_Endogenous_Product of
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