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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Proxyphylline
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Proxyphylline
NSC_Code
  • 163343
UMLS_CUI
  • C0072511
CAS_Registry
  • 603-00-9
FDA_UNII_Code
  • 13G1DMN4P0
Contributing_Source
  • FDA
Chemical_Formula
  • C10H14N4O3
Legacy_Concept_Name
  • Proxyphylline
FULL_SYN
  • PROXYPHYLLINEPTFDA13G1DMN4P0
  • ProxyphyllinePTNCI
  • Beta-OxypropyltheophyllinSYNCI
  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-SNNCI
  • TheonBRNCI
  • BrontylBRNCI
  • 1,3-Dimethyl-7-(2-hydroxypropyl)xanthineSNNCI
  • 2-Hydroxypropyl-7-theophyllineSYNCI
DEFINITION
  • A methylxanthine and derivative of theophylline. Proxyphylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Proxyphylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.NCI
code
  • C80339
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