About: Tacrolimus Anhydrous     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tacrolimus Anhydrous
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tacrolimus Anhydrous
UMLS_CUI
  • C0771204
CAS_Registry
  • 104987-11-3
FDA_UNII_Code
  • Y5L2157C4J
Contributing_Source
  • FDA
Chemical_Formula
  • C44H69NO12
Legacy_Concept_Name
  • Anhydrous_Tacrolimus
CHEBI_ID
  • CHEBI:61049
FULL_SYN
  • TACROLIMUS ANHYDROUSPTFDAY5L2157C4J
  • TsukubaenolideSYNCI
  • AvagrafSYNCI
  • AdvagrafSYNCI
  • Tacrolimus AnhydrousPTNCI
  • (-)-FK 506CNNCI
DEFINITION
  • Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.NCI
code
  • C76066
sameAs
http://linked.open...y/mesh/hasConcept
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