About: Salirasib     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Salirasib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Salirasib
UMLS_CUI
  • C0297001
CAS_Registry
  • 162520-00-5
FDA_UNII_Code
  • MZH0OM550M
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 573226
PDQ_Closed_Trial_Search_ID
  • 573226
Chemical_Formula
  • C22H30O2S
Legacy_Concept_Name
  • Salirasib
FULL_SYN
  • SALIRASIBPTFDAMZH0OM550M
  • S-Farnesylthiosalicylic AcidSNNCI
  • SalirasibPTNCI
  • 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic AcidSNNCI
DEFINITION
  • A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.NCI
code
  • C71146
http://linked.open...y/mesh/hasConcept
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