About: Silver Sulfadiazine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Silver Sulfadiazine
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Silver Sulfadiazine
UMLS_CUI
  • C0723179
CAS_Registry
  • 22199-08-2
FDA_UNII_Code
  • W46JY43EJR
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 717602
PDQ_Closed_Trial_Search_ID
  • 717602
Chemical_Formula
  • C10H9N4O2S.Ag
Legacy_Concept_Name
  • Sulfadiazine_Silver
CHEBI_ID
  • CHEBI:9142
FULL_SYN
  • SSDBRNCI
  • Silver SulfadiazinePTNCI
  • Sulfadiazine SilverSYNCI
  • SliverexBRNCI
  • SILVER SULFADIAZINEPTFDAW46JY43EJR
  • FlamazineFBNCI
  • SilvadeneBRNCI
  • ThermazeneBRNCI
DEFINITION
  • A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.NCI
code
  • C66567
sameAs
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