About: Rosuvastatin     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rosuvastatin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Rosuvastatin
UMLS_CUI
  • C0965129
CAS_Registry
  • 287714-41-4
FDA_UNII_Code
  • 413KH5ZJ73
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 654583
PDQ_Closed_Trial_Search_ID
  • 654583
Chemical_Formula
  • C22H28FN3O6S
Legacy_Concept_Name
  • Rosuvastatin
CHEBI_ID
  • CHEBI:38545
FULL_SYN
  • ROSUVASTATINPTFDA413KH5ZJ73
  • RosuvastatinPTNCI
DEFINITION
  • A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.NCI
code
  • C66523
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 55 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software