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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Merimepodib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Merimepodib
NSC_Code
  • 69811
  • 70969
UMLS_CUI
  • C1259636
CAS_Registry
  • 198821-22-6
FDA_UNII_Code
  • 2ZL2BA06FU
Contributing_Source
  • FDA
Chemical_Formula
  • C23H24N4O6
Legacy_Concept_Name
  • Merimepodib
FULL_SYN
  • MerimepodibPTNCI
  • MMPDABNCI
  • VX-497CNNCI
  • VI-21,497CNNCI
  • MERIMEPODIBPTFDA2ZL2BA06FU
  • Carbamic acid, ((3-((((3-methoxy-4-(5-oxazolyl)phenyl)amino)carbonyl)amino)phenyl)methyl)-, (3S)-tetrahydro-3-furanyl esterSNNCI
DEFINITION
  • An inosine monophosphate dehydrogenase (IMPDH) inhibitor with activity against hepatitis C virus (HCV). IMPDH catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, and treatment with merimepodib reduces the intracellular guanine nucleotide levels that are required for RNA and DNA synthesis, resulting in antiproliferative and antiviral effect.NCI
code
  • C66097
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