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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amodiaquine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amodiaquine
UMLS_CUI
  • C0002641
CAS_Registry
  • 86-42-0
FDA_UNII_Code
  • 220236ED28
Contributing_Source
  • FDA
Chemical_Formula
  • C20H22ClN3O
Legacy_Concept_Name
  • Amodiaquine
CHEBI_ID
  • CHEBI:2674
FULL_SYN
  • AmodiaquinePTNCI
  • AMODIAQUINEPTFDA220236ED28
DEFINITION
  • An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.NCI
code
  • C65231
sameAs
http://linked.open...y/mesh/hasConcept
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