About: Sinomenine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sinomenine
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Sinomenine
PubMedID_Primary_Reference
  • PMID: 16566946
UMLS_CUI
  • C0074568
CAS_Registry
  • 115-53-7
Legacy_Concept_Name
  • Sinomenine
FULL_SYN
  • Sabianine ASYNCI
  • CoculineSYNCI
  • CucolineSYNCI
  • 4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-oneSNNCI
  • SinomeninePTNCI
DEFINITION
  • An alkaloid isolated from the root of Sinomenium acutum with immunomodulatory and potential anti-angiogenic and activities. Although the mechanism of action remains to be fully elucidated, sinomenine appears to inhibit endothelial proliferation mediated through basic fibroblast growth factor (bFGF), which may contribute to its anti-angiogenic effect. In Chinese medicine, this agent has a long track-record in treating arthritis, which is accounted by its ability to inhibit proliferation of synovial fibroblasts and lymphocytes. In addition, sinomenine has been shown to suppress expressions of genes involved in inflammation and apoptosis, such as interleukin-6, a pleiotropic inflammatory cytokine and JAK3 (Janus kinase 3), Daxx (death-associated protein 6), plus HSP27 (heat shock 27kDa protein 1), respectively.NCI
code
  • C64766
http://linked.open...y/mesh/hasConcept
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