About: Multitargeted Tyrosine Kinase Inhibitor XL647

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About: Multitargeted Tyrosine Kinase Inhibitor XL647 Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Multitargeted Tyrosine Kinase Inhibitor XL647
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b723769 nodeID://b723770 nodeID://b723771 nodeID://b723772 nodeID://b723773
Has_Target	Receptor, Epidermal Growth Factor Receptors, Vascular Endothelial Growth Factor Receptor, erbB-2
Semantic_Type	Pharmacologic Substance
Preferred_Name	Multitargeted Tyrosine Kinase Inhibitor XL647
PubMedID_Primary_Reference	22011666
UMLS_CUI	C1541356
PDQ_Open_Trial_Search_ID	386183
PDQ_Closed_Trial_Search_ID	386183
Legacy_Concept_Name	XL647
FULL_SYN	Multitargeted Tyrosine Kinase Inhibitor XL647PTNCI KD019CNNCI XL647CNNCI
DEFINITION	An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression.NCI
code	C62496

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