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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Metoclopramide
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Metoclopramide
UMLS_CUI
  • C0025853
CAS_Registry
  • 364-62-5
FDA_UNII_Code
  • L4YEB44I46
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems and nausea and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility agent.NCI-GLOSS
Chemical_Formula
  • C14H22ClN3O2
Legacy_Concept_Name
  • Metoclopramide_Base
CHEBI_ID
  • CHEBI:107736
FULL_SYN
  • METOCLOPRAMIDEPTFDAL4YEB44I46
  • MetoclopramidePTNCI
  • metoclopramidePTNCI-GLOSSCDR0000045225
DEFINITION
  • A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.NCI
code
  • C62046
sameAs
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