About: Polymyxin B1 Sulfate     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Polymyxin B1 Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Polymyxin B1 Sulfate
UMLS_CUI
  • C1882418
CAS_Registry
  • 108965-61-3
FDA_UNII_Code
  • 57VAB21ZLF
Contributing_Source
  • FDA
Chemical_Formula
  • C56H98N16O13.H2SO4
Legacy_Concept_Name
  • Polymyxin_B1_Sulfate
FULL_SYN
  • POLYMYXIN B1 SULFATEPTFDA57VAB21ZLF
  • Polymyxin B1 SulfatePTNCI
DEFINITION
  • The sulfate salt form of polymyxin B1, a polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B1 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B1 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.NCI
code
  • C61897
is Has_Salt_Form of
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