About: Epiandrosterone     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Epiandrosterone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Epiandrosterone
UMLS_CUI
  • C0014483
CAS_Registry
  • 481-29-8
FDA_UNII_Code
  • 8TR252Z538
Contributing_Source
  • FDA
Chemical_Formula
  • C19H30O2
Legacy_Concept_Name
  • Epiandrosterone
CHEBI_ID
  • CHEBI:541975
FULL_SYN
  • EPIANDROSTERONEPTFDA8TR252Z538
  • EpiandrosteronePTNCI
DEFINITION
  • A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature.NCI
code
  • C61747
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