About: Ifosfamide

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Ifosfamide
rdfs:subClassOf	Nitrogen Mustard Compounds nodeID://b682141
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Organophosphorus Compound
Preferred_Name	Ifosfamide
NSC_Code	109724
UMLS_CUI	C0020823
CAS_Registry	3778-73-2
Accepted_Therapeutic_Use_For	Breast cancer; gastric carcinoma; lung cancer; lymphocytic leukemias; lymphoma; Hodgkins and Non-Hodgkins; ovarian cancer; pancreatic carcinoma; sarcomas; testicular cancer
In_Clinical_Trial_For	Neuroblastoma; non-small cell lung cancer; ovarian epithelial; fallopian tube; or peritoneal cancer; small cell lung cancer; urinary tract cancer Breast cancer; cancer of the urothelium; cancer of the uterus; Ewings sarcoma; germ cell tumor; lymphoblastic leukemia; lymphoma; metastatic rhabdomyosarcoma and other malignant mesenchymal tumors
FDA_UNII_Code	UM20QQM95Y
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used with other drugs to treat germ cell testicular cancer that did not respond to previous treatment with other drugs. It is also being studied in the treatment of other types of cancer. Ifex attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent and a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID	40024
PDQ_Closed_Trial_Search_ID	40024
Chemical_Formula	C7H15Cl2N2O2P
Legacy_Concept_Name	Ifosfamide
CHEBI_ID	CHEBI:5864
FULL_SYN	IphosphamidSYDTPNSC0109724 Asta Z-4942CNNCI Iso-EndoxanSYNCI IfosfamidumBRNCI IphosphamidSYNCI ifosfamidePTNCI-GLOSSCDR0000045267 IphosphamideSYDTPNSC0109724 IphosphamideSYNCI CyfosSYDTPNSC0109724 Z 4942SYDTPNSC0109724 IfexPTNCI-GLOSSCDR0000635888 N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxideSNNCI IsophosphamideSYNCI IFOABNCI IFXABNCI 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amineSNNCI IsophosphamideSYDTPNSC0109724 MJF 9325SYDTPNSC0109724 IfexBRNCI CyfosSYNCI NaxamideSYDTPNSC0109724 Z-4942CNNCI MitoxanaSYDTPNSC0109724 IfolemFBNCI IfoxanFBNCI IfomidaFBNCI IfomideSYNCI HoloxanFBNCI IFOSFAMIDEPTFDAUM20QQM95Y MJF-9325CNNCI IFO-CellFBNCI 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxideSNNCI NaxamideSYNCI SeromidaFBNCI HoloxaneFBNCI MitoxanaFBNCI TronoxalFBNCI Asta Z 4942SYDTPNSC0109724 IsoendoxanSYDTPNSC0109724 IfosfamidePTNCI IsoendoxanSYNCI
DEFINITION	A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)NCI
code	C564
sameAs	IFOSFAMIDE IFOSFAMIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0010999
is someValuesFrom of	nodeID://b642228 nodeID://b642238 nodeID://b645273 nodeID://b647151 nodeID://b647298 nodeID://b650726 nodeID://b650740 nodeID://b650743 nodeID://b650750 nodeID://b650769 nodeID://b650773 nodeID://b652297 nodeID://b654505 nodeID://b656770 nodeID://b656899 nodeID://b656935 nodeID://b656957 nodeID://b656999 nodeID://b657015 nodeID://b657023 nodeID://b657033 nodeID://b657037 nodeID://b657040 nodeID://b657042 nodeID://b657046 nodeID://b657052 nodeID://b657056 nodeID://b657061 nodeID://b657125 nodeID://b657192 nodeID://b657194 nodeID://b657197

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