About: HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine
UMLS_CUI
  • C1708269
PDQ_Open_Trial_Search_ID
  • 442901
PDQ_Closed_Trial_Search_ID
  • 442901
Legacy_Concept_Name
  • HER-2-neu_CEA_Peptides_GM-CSF_Montanide_ISA-51_Vaccine
FULL_SYN
  • HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 VaccinePTNCI
DEFINITION
  • A vaccine comprised of HER-2-neu and carcinoembryonic antigen synthetic (CEA) peptides, combined with the adjuvants granulocyte-macrophage colony stimulating factor (GM-CSF), and Montanide ISA-51 with potential antineoplastic activity. HER-2-neu, CEA peptides, GM-CSF, Montanide ISA-51 vaccine may stimulate a cytotoxic T-cell response against HER-2-neu- and CEA-expressing tumor cells. The GM-CSF adjuvant stimulates the proliferation of monocytes and monocyte differentiation into macrophages and dendritic cells, immunohematopoietic elements with important antitumoral functions. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens.NCI
code
  • C48392
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