About: Tiagabine Hydrochloride     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tiagabine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tiagabine Hydrochloride
UMLS_CUI
  • C0772200
CAS_Registry
  • 145821-59-6
FDA_UNII_Code
  • DQH6T6D8OY
Contributing_Source
  • FDA
Chemical_Formula
  • C20H25NO2S2.HCl
Legacy_Concept_Name
  • Tiagabine_Hydrochloride
FULL_SYN
  • Tiagabine HydrochloridePTNCI
  • TIAGABINE HYDROCHLORIDEPTFDADQH6T6D8OY
  • 3-Piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-yl)-, Hydrochloride,(R)-SNNCI
  • (-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid, HydrochlorideSNNCI
  • GabitrilBRNCI
  • NNC-05-0328CNNCI
DEFINITION
  • The hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. Tiagabine hydrochloride inhibits the gamma-aminobutyric acid (GABA) transporter type 1 (GAT1), which is predominantly localized in presynaptic terminals of neurons thereby preventing the reuptake of GABA by the presynaptic endings. Consequently, this increases the level of available GABA within the synaptic cleft, thereby resulting in prolongation of its inhibitory actions. Tiagabine is effective against maximum electroshock seizures and both limbic and generalized tonic-clonic seizures.NCI
code
  • C47755
sameAs
is Has_Salt_Form of
is sameAs of
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