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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sulfisoxazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sulfisoxazole
NSC_Code
  • 13120
  • 33807
  • 38588
UMLS_CUI
  • C0038745
CAS_Registry
  • 127-69-5
FDA_UNII_Code
  • 740T4C525W
Contributing_Source
  • FDA
Chemical_Formula
  • C11H13N3O3S
Legacy_Concept_Name
  • Sulfisoxazole
CHEBI_ID
  • CHEBI:102484
FULL_SYN
  • SULFISOXAZOLEPTFDA740T4C525W
  • SulfisoxazolePTNCI
  • 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamideSNNCI
DEFINITION
  • A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI
code
  • C47740
sameAs
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