About: Cycloleucine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cycloleucine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Cycloleucine
NSC_Code
  • 1026
UMLS_CUI
  • C0010575
CAS_Registry
  • 52-52-8
FDA_UNII_Code
  • 0TQU7668EI
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39200
PDQ_Closed_Trial_Search_ID
  • 39200
Chemical_Formula
  • C6H11NO2
Legacy_Concept_Name
  • Cycloleucine
FULL_SYN
  • CYCLOLEUCINEPTFDA0TQU7668EI
  • ACPCSYDTPNSC0001026
  • CycloleucineSYDTPNSC0001026
  • CycloleucinePTNCI
  • 1-aminocyclopentanecarboxylic acidSNNCI
  • 1-Aminocyclopentanecarboxylic acidSYDTPNSC0001026
  • CB 1639SYDTPNSC0001026
  • ACPABNCI
  • ACPCABNCI
  • CB-1639CNNCI
  • 1-AminocyclopentaneSYNCI
DEFINITION
  • A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.NCI
code
  • C404
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 13 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software