About: Interleukin-1 Receptor Alpha Type-I     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interleukin-1 Receptor Alpha Type-I
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • Interleukin-1 Receptor Alpha Type-I
UMLS_CUI
  • C1512837
Legacy_Concept_Name
  • Interleukin-1-Receptor_Alpha_Type-I
FULL_SYN
  • Interleukin-1 Receptor Alpha Type-IPTNCI
DEFINITION
  • Encoded by human IL1R1 Gene (IL1R Family), 569-aa 65-kDa (precursor) Interleukin-1 Receptor Alpha Type I is a type I membrane protein cytokine receptor for IL1A, IL1B, and IL1R1/IL1RA that binds to IL1RAP and contains 3 IgC2 domains and 1 TIR domain. An important mediator in many cytokine induced immune and inflammatory responses, agonist binding by IL1R1 leads to formation of a ternary signaling complex of IL1RAP/TOLLIP/MYD88/IRAK1 (or IRAK2) and NF-Kappa-B activation. (NCI)NCI
code
  • C38912
is someValuesFrom of
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