About: Gonadotropin-Releasing Hormone Receptor

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About: Gonadotropin-Releasing Hormone Receptor Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Gonadotropin-Releasing Hormone Receptor
rdfs:subClassOf	Receptors, G-Protein-Coupled nodeID://b677311 nodeID://b677312
Semantic_Type	Receptor
Preferred_Name	Gonadotropin-Releasing Hormone Receptor
UMLS_CUI	C0034811
Legacy_Concept_Name	Gonadotropin-Releasing_Hormone_Receptor
FULL_SYN	Gonadotropin-Releasing Hormone ReceptorPTNCI
DEFINITION	Gonadotropin-releasing hormone receptor protein (328 aa, 38 kD) is a cell communication process protein that is encoded by the human GNRHR gene and has a role in the G protein-coupled receptor signaling pathway.NCI
DesignNote	Expressed as 2 alternative isoforms in pituitary, ovary, testis, breast, and prostate by human GNRHR Gene (GPCR1 Family), Gonadotropin-Releasing Hormone Receptor is a cell surface G protein-coupled 7-transmembrane-domain receptor that transduces signals from hypothalamic decapeptide GNRH by association with G proteins that activate a calcium-phosphatidylinositol second messenger system. A neuroregulator of reproduction, the primary site of GNRH action is pituitary gonadotropes, which express GNRH receptors that modulate synthesis and secretion of gonadotropic hormones LH and FSH, which regulate gametogenic and hormonal functions of gonads. GNRHR Isoform 2 may act as an inhibitor of GNRHR signaling.
code	C38910
sameAs	Receptors, LHRH
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0018595
is someValuesFrom of	nodeID://b673282 nodeID://b673290 nodeID://b677323 nodeID://b686831 nodeID://b686835
is Has_Target of	Gonadotropin-Releasing Hormone Analogue Fertirelin
is sameAs of	Receptors, LHRH Receptors, LHRH

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