About: Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway
UMLS_CUI
  • C1512236
KEGG_ID
  • hsa00563
ALT_DEFINITION
  • Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis genes result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.KEGG
Legacy_Concept_Name
  • Glycosylphosphatidylinositol-anchor_Biosynthesis_Pathway
FULL_SYN
  • Glycosylphosphatidylinositol(GPI)-anchor BiosynthesisPTKEGG
  • Glycosylphosphatidylinositol-Anchor Biosynthesis PathwayPTNCI
  • GPI-Anchor Biosynthesis PathwaySYNCI
code
  • C38822
is someValuesFrom of
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