About: Membrane-Associated Guanylate Kinase Family Gene     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Membrane-Associated Guanylate Kinase Family Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Membrane-Associated Guanylate Kinase Family Gene
UMLS_CUI
  • C1334692
Legacy_Concept_Name
  • Membrane-Associated_Guanylate_Kinase_Family_Gene
FULL_SYN
  • MAGUK Family GeneSYNCI
  • Membrane-Associated Guanylate Kinase Family GenePTNCI
DEFINITION
  • Membrane-Associated Guanylate Kinase Family Genes encode MAGUK (Membrane-Associated GUanylate Kinase homolog) proteins containing DHR, SH3, and C-terminal GK-like domains. MAGUKs include Drosophila lethal(1)discs large-1 tumor suppressor protein (dlg1); mammalian Zo-1 tight junction protein; mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); 55 kD erythrocyte membrane protein (p55); C. elegans lin-2 protein; rat CASK protein; and human DLG2 and DLG3 proteins. An N-terminal ATP-binding site (P-loop) of Guanylate Kinase is not conserved in the MAGUK GK-like domain; MAGUKs do retain residues known in GK to bind GMP. (NCI)NCI
code
  • C25981
is rdfs:subClassOf of
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