About: Entinostat

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Entinostat
rdfs:subClassOf	Histone Deacetylase Inhibitor nodeID://b634987
Has_Target	Histone Deacetylases
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Entinostat
NSC_Code	706995
UMLS_CUI	C1510480
CAS_Registry	209783-80-2
In_Clinical_Trial_For	Hematologic cancer; lymphomas; solid tumors
FDA_UNII_Code	1ZNY4FKK9H
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	38294
PDQ_Closed_Trial_Search_ID	38294
Chemical_Formula	C21H20N4O3
Legacy_Concept_Name	MS-27-275
FULL_SYN	Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl EsterSNNCI entinostatPTNCI-GLOSSCDR0000630959 MS-275PTNCI-GLOSSCDR0000045014 MS-275PTDCP31823 Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI)SNNCI MS-275CNNCI N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamideSNNCI SNDX-275PTNCI-GLOSSCDR0000630957 HDAC inhibitor SNDX-275PTNCI-GLOSSCDR0000635095 ENTINOSTATPTFDA1ZNY4FKK9H SNDX-275CNNCI MS 27-275CNNCI EntinostatPTNCI
DEFINITION	A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.NCI
code	C1863
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0304185

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