About: Gemtuzumab Ozogamicin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Gemtuzumab Ozogamicin
rdfs:subClassOf	Anti-CD33 Immunotoxin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Immunologic Factor
Preferred_Name	Gemtuzumab Ozogamicin
NSC_Code	720568
UMLS_CUI	C1533699
CAS_Registry	220578-59-6
Accepted_Therapeutic_Use_For	Acute Myeloid Leukemia.
In_Clinical_Trial_For	Myelodysplastic Syndrome and Acute Promyelocytic Leukemia.
FDA_UNII_Code	8GZG754X6M
Contributing_Source	FDA
ALT_DEFINITION	A monoclonal antibody combined with a toxic substance that is used to treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Mylotarg is a type of antibody-drug conjugate.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42868
PDQ_Closed_Trial_Search_ID	42868
Chemical_Formula	C73H96IN6O25S3
Legacy_Concept_Name	Gemtuzumab_Ozogamicin
FULL_SYN	WAY-CMA-676CNNCI gemtuzumabPTNCI-GLOSSCDR0000508999 GEMTUZUMAB OZOGAMICINPTFDA8GZG754X6M Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal AntibodySYNCI CMA-676CNNCI CDP-771CNNCI gemtuzumab ozogamicinPTNCI-GLOSSCDR0000045569 MylotargPTNCI-GLOSSCDR0000509002 MylotargBRNCI hP67.6-CalicheamicinSYNCI Gemtuzumab OzogamicinPTNCI
DEFINITION	A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI04)NCI
code	C1806
sameAs	GEMTUZUMAB OZOGAMICIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0483090
is someValuesFrom of	nodeID://b647089 nodeID://b663904 nodeID://b664125 nodeID://b664249 nodeID://b664251 nodeID://b664254 nodeID://b676739
is sameAs of	GEMTUZUMAB OZOGAMICIN GEMTUZUMAB OZOGAMICIN

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