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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nucleophosmin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Nucleophosmin
UMLS_CUI
  • C0069141
Legacy_Concept_Name
  • Nucleophosmin
FULL_SYN
  • NucleophosminPTNCI
  • B23 Nuclear Matrix ProteinSYNCI
  • NPM1SYNCI
  • Nucleolar Phosphoprotein B23SYNCI
  • NumatrinSYNCI
DEFINITION
  • Nucleophosmin is a nucleolar phosphoprotein that is more abundant in tumor cells than in normal resting cells. Stimulation of the growth of normal cells, e.g., mitogen activation of B lymphocytes, is accompanied by an increase in nucleophosmin protein level. Although the function of nucleophosmin has not been defined precisely, ample evidence suggests that it is involved in the assembly of ribosomal proteins into ribosomes. Electron microscopic study indicates that nucleophosmin is concentrated in the granular region of the nucleolus, where ribosome assembly occurs. (from OMIM)NCI
  • A human nuclear matrix protein with demonstrated immunohistochemical staining differences between benign and malignant prostate tissue.NCI
code
  • C17570
http://linked.open...y/mesh/hasConcept
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