About: Plasminogen Activator Inhibitor 2     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Plasminogen Activator Inhibitor 2
rdfs:subClassOf
OMIM_Number
  • 173390
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Plasminogen Activator Inhibitor 2
UMLS_CUI
  • C0030191
Legacy_Concept_Name
  • Plasminogen_Activator_Inhibitor-2
FULL_SYN
  • Plasminogen Activator Inhibitor 2PTNCI
  • Plasminogen Activator Inhibitor-2SYNCI
  • PAISYNCI
  • Arginine-SerpinSYNCI
  • Serine or Cysteine Proteinase Inhibitor Clade B Member 2SYNCI
  • PAI-2ABNCI
  • PLANH2SYNCI
  • Plasminogen Activator Inhibitor Type IISYNCI
  • Monocyte Arg-SerpinSYNCI
  • SERPINB2SYNCI
  • Urokinase InhibitorSYNCI
  • Serpin B2SYNCI
  • Placental Plasminogen Activator InhibitorSYNCI
Swiss_Prot
  • P05120
DEFINITION
  • Plasminogen activator inhibitor 2 (415 aa, ~47 kDa) is encoded by the human SERPINB2 gene. This protein plays a role in the modulation of both plasmin activation and apoptosis.NCI
DesignNote
  • Plasminogen Activator Inhibitor-2 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. PAI2 (monocyte Arg-serpin) also belongs to the serine protease subfamily in which target specificity is determined by an Arg residue at its reactive center: Met/Val for elastase, Leu for kinase, and Arg for thrombin. PAI2 is thought to regulate plasminogen activation in extravascular compartments and high levels are found in keratinocytes, monocytes, and the trophoblast. (from OMIM 173390)
code
  • C16948
sameAs
http://linked.open...y/mesh/hasConcept
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