About: Gusperimus Trihydrochloride     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gusperimus Trihydrochloride
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Gusperimus Trihydrochloride
NSC_Code
  • 356894
UMLS_CUI
  • C0284559
CAS_Registry
  • 84937-45-1
In_Clinical_Trial_For
  • Prevention of Kidney Rejection.
FDA_UNII_Code
  • QZS4144IO0
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 40369
PDQ_Closed_Trial_Search_ID
  • 40369
Chemical_Formula
  • C17H37N7O3.3HCl
Legacy_Concept_Name
  • Gusperimus
FULL_SYN
  • 15-Deoxyspergualin HydrochlorideSNNCI
  • DSGABNCI
  • DeoxyspergualinSYNCI
  • 7-{(Aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamideSNNCI
  • (+-)-15-DeoxyspergualinSYDTPNSC0356894
  • Gusperimus TrihydrochloridePTNCI
  • 1-Amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dioneSNNCI
  • DeoxyspergualinSYDTPNSC0356894
  • NKT-01CNNCI
  • 15-DeoxyspergualinSNNCI
  • N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamideSNNCI
  • Deoxyspergualin HydrochlorideSYNCI
  • SpanidinFBNCI
  • BMS-181173CNNCI
  • GUSPERIMUS TRIHYDROCHLORIDEPTFDAQZS4144IO0
  • BMY-42215-1CNNCI
DEFINITION
  • A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04)NCI
code
  • C1598
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