About: Naphthalimide Analogue UNBS5162     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Naphthalimide Analogue UNBS5162
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Naphthalimide Analogue UNBS5162
UMLS_CUI
  • C2603824
CAS_Registry
  • 956590-23-1
PDQ_Open_Trial_Search_ID
  • 737303
PDQ_Closed_Trial_Search_ID
  • 737303
FULL_SYN
  • 1-(2-(2-(Dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)ureaSNNCI
  • UNBS5162CNNCI
  • Naphthalimide Analogue UNBS5162PTNCI
DEFINITION
  • An amonafide (naphthalimide) derivative and pan-antagonist of chemokine ligand (CXCL) expression, with potential anti-angiogenic activity. Although UNBS5162 is a derivative of amonafide, this agent appears to have a different profile to that of amonafide and its exact mechanism of action remains to be fully elucidated. This agent seems to decrease the expression of various proangiogenic CXCL chemokines in vitro and may have synergistic effects with radiotherapy or chemotherapy. CXCLs are small cytokines in the CXC chemokine family that are overexpressed in certain cancers; CXCL-mediated signaling plays a key role in angiogenesis and tumor progression.NCI
code
  • C102850
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