About: Regulation of the insulin secretion in polycystic ovary syndrome     Goto   Sponge   Distinct   Permalink

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  • Polycystic ovary syndrome (PCOS) is connected with insulin resistance and with disturbed insulin secretion , but the literary data are discrepant. Complex evaluation of the function of Langerhans islets has not been doen till now. Women with polycystic ovary syndrome will be evaluated with eugylcaemic hyperinsulinaemic clamp (insulin resistance) arginine test (secretion of insulin and glucagone) and oGTT (secretion of amylin and incretins). These methods will enable us to evaluate the adequacy of secretory compensation of insulin and some factors (incretins) involved in the regulation of insulin secretion. (en)
  • Syndrom polycystických ovarií (PCOS) je spojován s poruchou inzulínové senzitivity a sekrece inzulínu, ale dostupné údaje jsou kontroverzní. Funkce langerhansových ostrůvků (L.o.) ale zatím kompelxně sledována u PCOS nebyla. Ženy se syndromem polycystických ovarií (PCOS) budou vyšetřeny pomocí euglykemického clampu (inzulínová rezistence), argininového sekrečního testu (sekrece inzulínu a glukagonu), orálního glukózového tolerančního testu (sekrece inkretinů a amylinu). Navržené metodiky umožní zhodnotit adekvátnost sekreční kompenzace inzulínu vzhledem k úrovni inzulínové senzitivity a některé faktory, které se mohou podílet na regualci sekrece inzulínu. (cs)
Title
  • Regulation of the insulin secretion in polycystic ovary syndrome (en)
  • Regulace sekrece inzulínu u syndromu polycystických ovarií (cs)
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  • polycystic ovary syndrome; GLP-1; oGTT; insulin; amylin; diabetes mellitus; gĺucagone (en)
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