About: Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327 Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327
rdfs:subClassOf	Tyrosine Kinase Inhibitor
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327
UMLS_CUI	C2713088
PDQ_Open_Trial_Search_ID	596693
PDQ_Closed_Trial_Search_ID	596693
Legacy_Concept_Name	Multitargeted_Kinase_Inhibitor_JNJ-26483327
FULL_SYN	Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327PTNCI JNJ-26483327CNNCI TKI JNJ-26483327SYNCI
DEFINITION	An orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB).NCI
code	C77866

Faceted Search & Find service v1.16.121 as of Mar 31 2025

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 14 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software